A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones.

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A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones

Interaction of chromatin with the nuclear envelope and lamina is thought to help determine higher order chromosome organization in the interphase nucleus. Previous studies have shown that nuclear lamins bind chromatin directly. Here we have localized a chromatin binding site to the carboxyl-terminal tail domains of both A- and B-type mammalian lamins, and have characterized the biochemical prop...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1995

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.131.1.33